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They provide multiple avenues through which changes in the gut microbiome can influence central processes relevant to neurodegeneration (and vice versa)

Interventions aimed at reducing inflammation in animal models of ASD have been shown to have a positive effect on behavior and cognition, whilst simultaneously reducing neuroinflammation and supporting the restoration of neuronal integrity in key brain regions

Experiments have shown that 252 the accumulation of lactate in the TME entails acidification of the TME, and a lower extracellular pH has been shown to impair almost all aspects of CD8 + and CD4 + T lymphocyte function, including the activation of cytotoxicity, chemotactic motility, and proliferation 253,254